<MIBI 31014> <MIBI 31022> <MIBI 32034> <MIBI 32041> <MIBI 32052>

MIBI 32034

>< Type/Status : Elective
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Title : Medical, & Veterinary Microbiology and Microbial Technology
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Pre-requisite : MIBI 21014 & MIBI 21022
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Co-requisite : MIBI 32041
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Objectives : At the end of the course unit, the students will be able to demonstrate the knowledge and understanding of
the functioning of the immune system,
the common microbial disease agents, transmission, control and diagnosis,
some important microbial diseases in animals,
the conventional biotechnology and modern biotechnology,
the various stages of microbial process development,
growth kinetics and bio-engineering parameters of batch, continuous and fed-batch fermentation processes and solid state fermentation,
The microbial production of industrial chemicals, food-flavors, pharmaceuticals.
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Course content:

Medical Microbiology:
Host-microbe Interactions; Host defenses in vertebrates; non-specific and specific defense mechanisms. Cellular and Humoral immune responses; structure, formation and classes of immunoglobulins, Diagnostic Immunology, Disorders associated with the Immune system, Important microbial diseases of skin, respiratory, gastrointestinal, genitourinary and nervous.

Veterinary Microbiology:
Aetiology, transmission, pathogenesis and diagnosis of common microbial diseases of poultry in Sri Lanka. Chronic respiratory disease, Gumboro disease, Avian encephalitis, Ranikhet (New Castle), Fowl pox, Fowl cholera, Coccidiosis, Pullorum disease.
Important microbial diseases in cattle, Hemorrhagic septicemia, Mastitis, Foot & mouth disease, Rinderpest - aetiology, transmission, pathogenesis and diagnosis. Microbial diseases of pigs: swine fever, diarrhea.

Microbial technology:
The nature of biotechnology, historical evolution of biotechnology, Growth application and strategic planning in biotechnology.
Basic principles of biochemical engineering and its role in the development of fermentation technology; Unit operations, unit processes, process design. Microbial growth kinetics, batch preservation and improvement of industrial microorganisms. Primary metabolites and Secondary metabolites. Fermentation technology Bio-reactors, media design, measurement techniques, Solid Substrate Fermentation (SSF). Application of microbial technology, microbial production of ethanol, wine, beer, lactic acid, vinegar, amino acids, antibiotics, enzymes soy sauce, bio-gas generation. Basic principles in cosmetic microbiology.

>< Methodology: A combination of lectures and tutorials.
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Scheme of Evaluation: 100% end of course examination.
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Recommended Reading:
1. Atlas, R. (1997) Principles of Microbiology. Wm. C. Brown, Boston, UAS. .
Cruger, W. and Cruger, A. (1990) Biotechnology A text book of industrial microbiology. Science Tech. Inc. Madison.

2. Greenwood, D., Slack, R. C. B., Peutherer, J. F. (1997) Medical microbiology(15th Ed): Churchill Livingstone, UK.
3. Prave, P., Faust, U., Sttigg, W. and Sukatsch, D. A. (1982) Biotechnology – A student’s guide. VCH Vergasgesllschaft, Germany.
4. Turgeon, M. L (1995) Immunology and serology in laboratory. 2nd ed. Plenum Press, New York.

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