CHEM 43024

>< Type/Status : Compulsory
>< Title : Advanced Organic Chemistry I
>< Objectives : To provide advanced aspects in Organic Chemistry.
>< Course Content :

Concerted Reactions

Electrocyclic reactions, sigmatropic rearrangements and cycloaddition reactions.

Reaction Intermediates, Mechanisms and Stereochemistry

Generation of carbocations, neighbouring group participation, norbornyl carbocation, carbanions; hydrocarbon acidity, stability & rearrangements; E1, E2, E1cb elimination reactions, isotope effects, carbenes and free radicals, substituent effects and linear free energy relationships, prostereoisomerism, dynamic stereochmistry.

Advanced Spectroscopic Methods in Organic Chemistry

NMR spectra; non first order spectra, simplification of complex spectra (shift reagents,INDOR), 13C NMR, chemical shifts and signal intensities, pulsed techniques, DEPT, gated decoupling, 2D NMR. Mass spectrometry; high resolution spectra, MALDI ToF, chemical ionization techniques, GC-MS, ORD and CD techniques.

Heterocyclic Chemistry

Chemistry of aromatic heterocylic compounds containing one and two hetero atoms.

>< Process : A combination of lectures and tutorials.
>< Scheme of Evaluation : 100% end of course examination
>< Recommended Reading :
1. Gupta, R. R., Kumar, M. and Gupta, V. (1999), Heterocyclic Chemistry, Vol. II, Springer.
2. Joule, J. A., Mills, K. and Smith, G. F. (1995), Heterocyclic Chemistry: 3rd edition, Chapman.
3. Carey, F. A. and Sundburg, R. J. (2000), Advanced Organic Chemistry Part A, 4th edition, Plenum.
4. Buxton and Roberts, S. M. (1996), Guide to Organic Stereochemistry, Longman.
5. Testa, B. (1979), Principles of Organic Stereochemistry, Marcel Dekker.
6. Hesse, M, Meier, H. and Zeeh, B. (1998), Spectroscopic Methods in Organic Chemistry, John Wiley.
7. Crew, J., Rodriguez, J. and Jaspars, M. (1998), Organic Structure Analysis, 2nd edition, Oxford.

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