CHEM 43034

>< Type/Status : Compulsory
>< Title : Biochemistry I
>< Objectives : To provide the basics of biomolecules and metabolism
>< Course Content :

Proteins
Principles and patterns of protein structure, prediction of protein structure, protein design, specialised purification procedures; of membrane proteins, DNA binding proteins glycoproteins and multienzyme complexes. Protein crystallisation and radio labelling of proteins.

Enzymes
Principles of enzyme catalysis. Advanced methods of enzyme kinetics and inhibition. Structure and mechanisms of selected enzymes.

Nucleic Acids
Nucleic acid structure, replication, transcription and protein synthesis, mutations and DNA repair, genetic recombination. Chromosome structure and organization.

Lipids and Membranes
Structure and functions of biologically important lipids and membranes and mechanisms of membrane transport.

Metabolism
Major metabolic pathways and control sites of carbohydrate metabolism, lipid metabolism, amino acid metabolism and integration of metabolism.

>< Process : A combination of lectures and tutorials.
>< Scheme of Evaluation : 100% end of course examination
>< Recommended Reading :
1. Stryer, L. (1995), Biochemistry, 4th edition, Freeman.
2. Voet, D. and Voet, J. G. (1995), Biochemistry, John Wiley.
3. Vanholde, M. (1990), Biochemistry, Benjamin.
4. Lehninger, L., Nelson, D. L. and Cox, M. M. (1993), Principles of Biochemistry, Worth.
5. Creighton, T. E. (1993), Proteins, Oxford.
6. Fersht, A. (1993), Enzyme Structure and Mechanism, Freeman.
7. Laurence, M. and Scrimgeour, K. G. (1994), Biochemistry, Prentice Hall.

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